DOT1L gene

From NCBI Gene:

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

From UniProt:

Covered on Genetics Home Reference:

• Osteoarthritis

Cytogenetic Location: 19p13.3, which is the short (p) arm of chromosome 19 at position 13.3

Molecular Location: base pairs 2,163,933 to 2,232,578 on chromosome 19 (Homo sapiens Updated Annotation Release 109.20200228, GRCh38.p13) (NCBI)

• DOT1
• KMT4