DOT1L gene
DOT1 like histone lysine methyltransferase
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
From UniProt:
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190).
Related Information
Covered on Genetics Home Reference:
Related Information
Cytogenetic Location: 19p13.3, which is the short (p) arm of chromosome 19 at position 13.3
Molecular Location: base pairs 2,163,963 to 2,232,578 on chromosome 19 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- DOT1
- KMT4