DLC1 gene

DLC1 Rho GTPase activating protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

From UniProt:

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22

Molecular Location: base pairs 13,083,361 to 13,604,606 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22
  • ARHGAP7
  • HP
  • p122-RhoGAP
  • STARD12