DIRC2 gene

disrupted in renal carcinoma 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]

From UniProt:

Electrogenic metabolite transporter.

From NCBI Gene:

  • Renal cell carcinoma, nonpapillary

From UniProt:

A chromosomal aberration involving DIRC2 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21) (PubMed:11912179).

Cytogenetic Location: 3q21.1, which is the long (q) arm of chromosome 3 at position 21.1

Molecular Location: base pairs 122,795,054 to 122,892,157 on chromosome 3 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 3q21.1, which is the long (q) arm of chromosome 3 at position 21.1