DGKE gene

diacylglycerol kinase epsilon

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

From UniProt:

Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

From NCBI Gene:

  • Nephrotic syndrome, type 7

From UniProt:

Nephrotic syndrome 7 (NPHS7): A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. NPHS7 is an autosomal recessive form characterized by onset of proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis. [MIM:615008]

Hemolytic uremic syndrome atypical 7 (AHUS7): An atypical form of hemolytic uremic syndrome characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system. [MIM:615008]

Cytogenetic Location: 17q22, which is the long (q) arm of chromosome 17 at position 22

Molecular Location: base pairs 56,834,131 to 56,869,567 on chromosome 17 (Homo sapiens Updated Annotation Release 109.20200228, GRCh38.p13) (NCBI)

Cytogenetic Location: 17q22, which is the long (q) arm of chromosome 17 at position 22
  • AHUS7
  • DAGK5
  • DAGK6
  • DGK
  • NPHS7