DEK gene

DEK proto-oncogene

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

From UniProt:

Involved in chromatin organization.

From UniProt:

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).

Cytogenetic Location: 6p22.3, which is the short (p) arm of chromosome 6 at position 22.3

Molecular Location: base pairs 18,224,169 to 18,264,568 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6p22.3, which is the short (p) arm of chromosome 6 at position 22.3
  • D6S231E