DAOA gene

D-amino acid oxidase activator

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

From UniProt:

Seems to activate D-amino acid oxidase.

From NCBI Gene:

  • Schizophrenia

From UniProt:

Schizophrenia (SCZD): A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. [MIM:181500]

Cytogenetic Location: 13q33.2, which is the long (q) arm of chromosome 13 at position 33.2

Molecular Location: base pairs 105,465,867 to 105,491,034 on chromosome 13 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 13q33.2, which is the long (q) arm of chromosome 13 at position 33.2
  • LG72
  • SG72