DAB1 gene

DAB1, reelin adaptor protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]

From UniProt:

Adapter molecule functioning in neural development. May regulate SIAH1 activity.

From NCBI Gene:

  • Spinocerebellar ataxia 37

From UniProt:

Spinocerebellar ataxia 37 (SCA37): A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA37 is an autosomal dominant form characterized by adult-onset of slowly progressive gait instability, frequent falls, and dysarthria associated with cerebellar atrophy on brain imaging. [MIM:615945]

Cytogenetic Location: 1p32.2, which is the short (p) arm of chromosome 1 at position 32.2

Molecular Location: base pairs 56,997,906 to 58,250,539 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p32.2, which is the short (p) arm of chromosome 1 at position 32.2