CX3CR1 gene

C-X3-C motif chemokine receptor 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

From UniProt:

Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932).

Covered on Genetics Home Reference:

From NCBI Gene:

  • Age-related macular degeneration 12
  • Coronary heart disease 1
  • Human immunodeficiency virus type 1, susceptibility to

From UniProt:

Macular degeneration, age-related, 12 (ARMD12): A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. [MIM:613784]

Cytogenetic Location: 3p22.2, which is the short (p) arm of chromosome 3 at position 22.2

Molecular Location: base pairs 39,263,494 to 39,281,735 on chromosome 3 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 3p22.2, which is the short (p) arm of chromosome 3 at position 22.2
  • CCRL1
  • CMKDR1
  • GPR13
  • GPRV28
  • V28