CUX2 gene

cut like homeobox 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

From UniProt:

Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.

From NCBI Gene:

  • EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 67

From UniProt:

Epileptic encephalopathy, early infantile, 67 (EIEE67): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE67 is an autosomal dominant form characterized by onset of seizures in infancy. Later onset of seizures in childhood may occur in some patients. [MIM:618141]

Cytogenetic Location: 12q24.11-q24.12, which is the long (q) arm of chromosome 12 between positions 24.11 and 24.12

Molecular Location: base pairs 111,034,165 to 111,350,556 on chromosome 12 (Homo sapiens Updated Annotation Release 109.20190905, GRCh38.p13) (NCBI)

Cytogenetic Location: 12q24.11-q24.12, which is the long (q) arm of chromosome 12 between positions 24.11 and 24.12
  • CDP2
  • CUTL2
  • EIEE67