CRADD gene

CASP2 and RIPK1 domain containing adaptor with death domain

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

From UniProt:

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).

From NCBI Gene:

  • Mental retardation, autosomal recessive 34

From UniProt:

Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. [MIM:614499]

Cytogenetic Location: 12q22, which is the long (q) arm of chromosome 12 at position 22

Molecular Location: base pairs 93,677,342 to 93,894,840 on chromosome 12 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 12q22, which is the long (q) arm of chromosome 12 at position 22
  • MRT34
  • RAIDD