CR1 gene

complement C3b/C4b receptor 1 (Knops blood group)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

From UniProt:

(Microbial infection) Acts as a receptor for Epstein-Barr virus.

Mediates cellular binding of particles and immune complexes that have activated complement.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Susceptibility to malaria
  • KNOPS BLOOD GROUP SYSTEM

Cytogenetic Location: 1q32, which is the long (q) arm of chromosome 1 at position 32

Molecular Location: base pairs 207,496,128 to 207,641,765 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q32, which is the long (q) arm of chromosome 1 at position 32
  • C3BR
  • C4BR
  • CD35
  • KN