COL8A1 gene

collagen type VIII alpha 1 chain

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]

From UniProt:

Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.

Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Cytogenetic Location: 3q12.1, which is the long (q) arm of chromosome 3 at position 12.1

Molecular Location: base pairs 99,638,596 to 99,796,733 on chromosome 3 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 3q12.1, which is the long (q) arm of chromosome 3 at position 12.1
  • C3orf7