CLMP gene

CXADR like membrane protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

From UniProt:

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

From NCBI Gene:

  • Congenital short bowel syndrome

From UniProt:

Congenital short bowel syndrome (CSBS): A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life. [MIM:615237]

Cytogenetic Location: 11q24.1, which is the long (q) arm of chromosome 11 at position 24.1

Molecular Location: base pairs 123,072,006 to 123,195,305 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q24.1, which is the long (q) arm of chromosome 11 at position 24.1
  • ACAM
  • ASAM
  • CSBM
  • CSBS