CLEC7A gene

C-type lectin domain family 7 member A

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

From UniProt:

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Aspergillosis, susceptibility to
  • Familial chronic mucocutaneous candidiasis

From UniProt:

Candidiasis, familial, 4 (CANDF4): A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. [MIM:613108]

Cytogenetic Location: 12p13.2, which is the short (p) arm of chromosome 12 at position 13.2

Molecular Location: base pairs 10,116,777 to 10,130,269 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12p13.2, which is the short (p) arm of chromosome 12 at position 13.2
  • BGR
  • CANDF4
  • CD369
  • CLECSF12
  • SCARE2