CLDN10 gene

claudin 10

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

From UniProt:

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney.

Cytogenetic Location: 13q32.1, which is the long (q) arm of chromosome 13 at position 32.1

Molecular Location: base pairs 95,433,588 to 95,579,756 on chromosome 13 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 13q32.1, which is the long (q) arm of chromosome 13 at position 32.1
  • CPETRL3
  • HELIX
  • OSP-L
  • OSPL