CLCN4 gene
chloride voltage-gated channel 4
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
From UniProt:
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.
Related Information
From NCBI Gene:
- Mental retardation 49, X-linked
From UniProt:
Mental retardation, X-linked 49 (MRX49): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. [MIM:300114]
Related Information
Cytogenetic Location: Xp22.2, which is the short (p) arm of the X chromosome at position 22.2
Molecular Location: base pairs 10,156,945 to 10,237,660 on the X chromosome (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- ClC-4
- ClC-4A
- CLC4
- MRX15
- MRX49
- MRXSRC