CIT gene

citron rho-interacting serine/threonine kinase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

From UniProt:

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

From NCBI Gene:

  • MICROCEPHALY 17, PRIMARY, AUTOSOMAL RECESSIVE

Cytogenetic Location: 12q24.23, which is the long (q) arm of chromosome 12 at position 24.23

Molecular Location: base pairs 119,685,790 to 119,877,318 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12q24.23, which is the long (q) arm of chromosome 12 at position 24.23
  • CITK
  • CRIK
  • MCPH17
  • STK21