CHRNA3 gene

cholinergic receptor nicotinic alpha 3 subunit

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

From UniProt:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Cytogenetic Location: 15q25.1, which is the long (q) arm of chromosome 15 at position 25.1

Molecular Location: base pairs 78,593,052 to 78,621,295 on chromosome 15 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 15q25.1, which is the long (q) arm of chromosome 15 at position 25.1
  • LNCR2
  • NACHRA3
  • PAOD2