CFAP65 gene

cilia and flagella associated protein 65

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene has putative coiled-coil domains and may be a transmembrane protein. The chicken ortholog of this gene is involved in the Rose-comb mutation, which is a large chromosome inversion, resulting in altered comb morphology and defects in sperm motility. [provided by RefSeq, Aug 2016]

From UniProt:

Plays a role in flagellar formation and sperm motility.

From NCBI Gene:

  • SPERMATOGENIC FAILURE 40

From UniProt:

Spermatogenic failure 40 (SPGF40): An autosomal recessive infertility disorder characterized by severely reduced or absent sperm motility, due to multiple morphologic anomalies such as absent, short, bent, coiled and irregular-caliber tails. Patient spermatozoa may also show morphologic defects of the sperm head. [MIM:618664]

Cytogenetic Location: 2q35, which is the long (q) arm of chromosome 2 at position 35

Molecular Location: base pairs 219,002,846 to 219,043,142 on chromosome 2 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 2q35, which is the long (q) arm of chromosome 2 at position 35
  • CCDC108
  • SPGF40