CDCA7 gene

cell division cycle associated 7

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

From UniProt:

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.

From NCBI Gene:

  • Immunodeficiency-centromeric instability-facial anomalies syndrome 3

From UniProt:

Immunodeficiency-centromeric instability-facial anomalies syndrome 3 (ICF3): A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients. [MIM:616910]

Cytogenetic Location: 2q31, which is the long (q) arm of chromosome 2 at position 31

Molecular Location: base pairs 173,354,017 to 173,368,992 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q31, which is the long (q) arm of chromosome 2 at position 31
  • ICF3
  • JPO1