CD82 gene

From NCBI Gene:

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Covered on Genetics Home Reference:

• prostate cancer

From NCBI Gene:

• Malignant tumor of prostate

Cytogenetic Location: 11p11.2, which is the short (p) arm of chromosome 11 at position 11.2

Molecular Location: base pairs 44,565,591 to 44,620,363 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

• 4F9
• C33
• GR15
• IA4
• KAI1
• R2
• SAR2
• ST6
• TSPAN27