CD79B gene

CD79b molecule

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

From UniProt:

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

From NCBI Gene:

  • Agammaglobulinemia 6, autosomal recessive

From UniProt:

Agammaglobulinemia 6, autosomal recessive (AGM6): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. [MIM:612692]

Cytogenetic Location: 17q23.3, which is the long (q) arm of chromosome 17 at position 23.3

Molecular Location: base pairs 63,928,738 to 63,932,344 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q23.3, which is the long (q) arm of chromosome 17 at position 23.3
  • AGM6
  • B29
  • IGB