CCL3L1 gene

C-C motif chemokine ligand 3 like 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

From UniProt:

Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

From NCBI Gene:

  • Human immunodeficiency virus type 1, susceptibility to

Cytogenetic Location: 17q21.1, which is the long (q) arm of chromosome 17 at position 21.1

Molecular Location: base pairs 250,577 to 252,466 on chromosome 17 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 17q21.1, which is the long (q) arm of chromosome 17 at position 21.1
  • 464.2
  • D17S1718
  • G0S19-2
  • LD78
  • LD78-beta(1-70)
  • LD78BETA
  • MIP1AP
  • SCYA3L
  • SCYA3L1