CCL2 gene

C-C motif chemokine ligand 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

From UniProt:

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

From NCBI Gene:

  • Human immunodeficiency virus type 1, susceptibility to
  • Mycobacterium tuberculosis, susceptibility to
  • Neural tube defect

Cytogenetic Location: 17q11.2-q12, which is the long (q) arm of chromosome 17 between positions 11.2 and 12

Molecular Location: base pairs 34,255,277 to 34,257,203 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q11.2-q12, which is the long (q) arm of chromosome 17 between positions 11.2 and 12
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • MCP-1
  • MCP1
  • SCYA2
  • SMC-CF