CCDC6 gene

coiled-coil domain containing 6

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

From NCBI Gene:

  • Papillary thyroid carcinoma

From UniProt:

A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

Cytogenetic Location: 10q21, which is the long (q) arm of chromosome 10 at position 21

Molecular Location: base pairs 59,788,747 to 59,906,656 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q21, which is the long (q) arm of chromosome 10 at position 21
  • D10S170
  • H4
  • PTC
  • TPC
  • TST1