caspase recruitment domain family member 14
The CARD14 gene provides instructions for making a protein that turns on (activates) a group of interacting proteins known as nuclear factor-kappa-B (NF-κB). The NF-κB protein complex regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).
The CARD14 protein is found in many of the body's tissues, but it is particularly abundant in the skin. NF-κB signaling appears to play important roles in regulating inflammatory reactions in the skin and in promoting the survival of skin cells.
At least three mutations in the CARD14 gene have been identified in people with familial pityriasis rubra pilaris, a rare hereditary skin condition. These mutations lead to overactivation of NF-κB signaling, which triggers an abnormal inflammatory response in the skin. Researchers are working to determine how these changes lead to the specific features of familial pityriasis rubra pilaris.
Genetics Home Reference provides information about psoriatic arthritis.
Changes in the CARD14 gene may also contribute to a common inflammatory skin disorder called psoriasis. At least two mutations have been identified in families with psoriasis or psoriatic arthritis (a similar condition characterized by both skin and joint inflammation). Several other rare variants of the CARD14 gene have been associated with an increased risk of psoriasis in people without a family history of the disorder. Studies suggest that these genetic changes may enhance activation of NF-κB, increasing the activity of genes involved in the body's inflammatory response. The resulting abnormal inflammation is a characteristic feature of psoriasis and psoriatic arthritis. However, CARD14 gene mutations appear to be an uncommon risk factor for these complex conditions, which likely result from a combination of genetic and environmental factors.
- bcl10-interacting maguk protein 2
- CARD-containing MAGUK protein 2
- card-maguk protein 2
- carma 2
- caspase recruitment domain-containing protein 14
- caspase recruitment domain family, member 14