CACNA2D1 gene

calcium voltage-gated channel auxiliary subunit alpha2delta 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]

From UniProt:

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.

Cytogenetic Location: 7q21.11, which is the long (q) arm of chromosome 7 at position 21.11

Molecular Location: base pairs 81,946,444 to 82,443,921 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7q21.11, which is the long (q) arm of chromosome 7 at position 21.11
  • CACNA2
  • CACNL2A
  • CCHL2A
  • LINC01112
  • lncRNA-N3