C9orf3 gene

chromosome 9 open reading frame 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

From UniProt:

Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.

Cytogenetic Location: 9q22.32, which is the long (q) arm of chromosome 9 at position 22.32

Molecular Location: base pairs 94,726,669 to 95,148,264 on chromosome 9 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 9q22.32, which is the long (q) arm of chromosome 9 at position 22.32
  • AOPEP
  • AP-O
  • APO
  • C90RF3
  • ONPEP