BTNL2 gene

butyrophilin like 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]

From UniProt:

Negative regulator of T-cell proliferation.

From NCBI Gene:

  • Sarcoidosis 2

From UniProt:

Sarcoidosis 2 (SS2): An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. [MIM:612387]

Cytogenetic Location: 6p21.32, which is the short (p) arm of chromosome 6 at position 21.32

Molecular Location: base pairs 32,393,339 to 32,408,879 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6p21.32, which is the short (p) arm of chromosome 6 at position 21.32
  • BTL-II
  • BTN7
  • HSBLMHC1
  • SS2