BTG1 gene

BTG anti-proliferation factor 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

From UniProt:

Anti-proliferative protein.

From UniProt:

A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

Cytogenetic Location: 12q22, which is the long (q) arm of chromosome 12 at position 22

Molecular Location: base pairs 92,140,278 to 92,145,897 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12q22, which is the long (q) arm of chromosome 12 at position 22