BRWD3 gene
bromodomain and WD repeat domain containing 3
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene are associated with a spectrum of cognitive disabilities and X-linked macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. [provided by RefSeq, Jul 2017]
From UniProt:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Related Information
From NCBI Gene:
- Mental retardation, X-linked 93
From UniProt:
Mental retardation, X-linked 93 (MRX93): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX93 is associated with macrocephaly. [MIM:300659]
A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.
Related Information
Cytogenetic Location: Xq21.1, which is the long (q) arm of the X chromosome at position 21.1
Molecular Location: base pairs 80,669,488 to 80,809,736 on the X chromosome (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- BRODL
- MRX93