BRD3 gene

bromodomain containing 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

From UniProt:

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

From UniProt:

A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

Cytogenetic Location: 9q34.2, which is the long (q) arm of chromosome 9 at position 34.2

Molecular Location: base pairs 134,030,305 to 134,068,533 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q34.2, which is the long (q) arm of chromosome 9 at position 34.2
  • ORFX
  • RING3L