BRD3 gene

bromodomain containing 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

From UniProt:

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets.

From UniProt:

A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

Cytogenetic Location: 9q34.2, which is the long (q) arm of chromosome 9 at position 34.2

Molecular Location: base pairs 134,030,305 to 134,068,533 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q34.2, which is the long (q) arm of chromosome 9 at position 34.2
  • ORFX
  • RING3L