BCO1 gene

beta-carotene oxygenase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]

From UniProt:

Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.

From NCBI Gene:

  • Hypercarotenemia and vitamin a deficiency, autosomal dominant

From UniProt:

Hypercarotenemia and vitamin A deficiency, autosomal dominant (ADHVAD): A disorder characterized by increased serum beta-carotene, decreased conversion of beta-carotene to vitamin A and decreased serum vitamin A. [MIM:115300]

Cytogenetic Location: 16q23.2, which is the long (q) arm of chromosome 16 at position 23.2

Molecular Location: base pairs 81,238,642 to 81,291,142 on chromosome 16 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 16q23.2, which is the long (q) arm of chromosome 16 at position 23.2
  • BCDO
  • BCDO1
  • BCMO
  • BCMO1
  • BCO