BCL9 gene

B-cell CLL/lymphoma 9

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]

From UniProt:

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity.

Covered on Genetics Home Reference:

From UniProt:

A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.

Cytogenetic Location: 1q21.2, which is the long (q) arm of chromosome 1 at position 21.2

Molecular Location: base pairs 147,541,394 to 147,626,219 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q21.2, which is the long (q) arm of chromosome 1 at position 21.2