BCL11B gene

B-cell CLL/lymphoma 11B

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

From UniProt:

Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.

Cytogenetic Location: 14q32.2, which is the long (q) arm of chromosome 14 at position 32.2

Molecular Location: base pairs 99,169,287 to 99,271,713 on chromosome 14 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 14q32.2, which is the long (q) arm of chromosome 14 at position 32.2
  • ATL1
  • ATL1-alpha
  • ATL1-beta
  • ATL1-delta
  • ATL1-gamma
  • CTIP-2
  • CTIP2
  • hRIT1-alpha
  • IMD49
  • RIT1
  • ZNF856B