basal cell adhesion molecule (Lutheran blood group)
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Laminin alpha-5 receptor. May mediate intracellular signaling.
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
- HGNC Gene Family: Blood group antigens
- HGNC Gene Family: C2-set domain containing
- HGNC Gene Family: CD molecules
- HGNC Gene Family: Ig-like cell adhesion molecule family
- HGNC Gene Family: Immunoglobulin like domain containing
- HGNC Gene Symbol Report
- NCBI Gene