ARHGAP32 gene

Rho GTPase activating protein 32

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

From UniProt:

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.

Cytogenetic Location: 11q24.3, which is the long (q) arm of chromosome 11 at position 24.3

Molecular Location: base pairs 128,965,060 to 129,279,168 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q24.3, which is the long (q) arm of chromosome 11 at position 24.3
  • GC-GAP
  • GRIT
  • p200RhoGAP
  • p250GAP
  • PX-RICS
  • RICS