ARHGAP26 gene

Rho GTPase activating protein 26

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

From UniProt:

GTPase-activating protein for RHOA and CDC42.

From NCBI Gene:

  • Juvenile myelomonocytic leukemia

From UniProt:

Leukemia, juvenile myelomonocytic (JMML): An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. [MIM:607785]

Cytogenetic Location: 5q31.3, which is the long (q) arm of chromosome 5 at position 31.3

Molecular Location: base pairs 142,770,370 to 143,229,007 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q31.3, which is the long (q) arm of chromosome 5 at position 31.3
  • GRAF
  • GRAF1
  • OPHN1L
  • OPHN1L1