ARAF gene

A-Raf proto-oncogene, serine/threonine kinase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

From UniProt:

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.

Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Cytogenetic Location: Xp11.3, which is the short (p) arm of the X chromosome at position 11.3

Molecular Location: base pairs 47,561,100 to 47,571,921 on the X chromosome (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: Xp11.3, which is the short (p) arm of the X chromosome at position 11.3
  • A-RAF
  • ARAF1
  • PKS2
  • RAFA1