APOPT1 gene

apoptogenic 1, mitochondrial

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that localizes to the mitochondria, where it stimulates the release of cytochrome c, thereby promoting programmed cell death. Mutations in this gene have been found in individuals with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

From UniProt:

Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade.

Cytogenetic Location: 14q32.33, which is the long (q) arm of chromosome 14 at position 32.33

Molecular Location: base pairs 103,562,957 to 103,592,187 on chromosome 14 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 14q32.33, which is the long (q) arm of chromosome 14 at position 32.33
  • APOP
  • APOP1
  • C14orf153