APCDD1 gene

APC down-regulated 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]

From UniProt:

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.

From NCBI Gene:

  • Hypotrichosis simplex

From UniProt:

Hypotrichosis 1 (HYPT1): A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age. [MIM:605389]

Cytogenetic Location: 18p11.22, which is the short (p) arm of chromosome 18 at position 11.22

Molecular Location: base pairs 10,454,628 to 10,488,701 on chromosome 18 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 18p11.22, which is the short (p) arm of chromosome 18 at position 11.22
  • B7323
  • DRAPC1
  • FP7019
  • HHS
  • HTS
  • HYPT1