APBB2 gene

amyloid beta precursor protein binding family B member 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

From UniProt:

May modulate the internalization of beta-amyloid precursor protein.

Cytogenetic Location: 4p14-p13, which is the short (p) arm of chromosome 4 between positions 14 and 13

Molecular Location: base pairs 40,810,027 to 41,216,714 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4p14-p13, which is the short (p) arm of chromosome 4 between positions 14 and 13
  • FE65L
  • FE65L1