ANLN gene

anillin actin binding protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

From UniProt:

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).

From NCBI Gene:

  • Focal segmental glomerulosclerosis 8

From UniProt:

Focal segmental glomerulosclerosis 8 (FSGS8): A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. [MIM:616032]

Cytogenetic Location: 7p15-p14, which is the short (p) arm of chromosome 7 between positions 15 and 14

Molecular Location: base pairs 36,389,803 to 36,453,791 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7p15-p14, which is the short (p) arm of chromosome 7 between positions 15 and 14
  • FSGS8
  • scra
  • Scraps