ALOX5 gene

arachidonate 5-lipoxygenase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

From UniProt:

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Cytogenetic Location: 10q11.2, which is the long (q) arm of chromosome 10 at position 11.2

Molecular Location: base pairs 45,374,166 to 45,446,121 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q11.2, which is the long (q) arm of chromosome 10 at position 11.2
  • 5-LO
  • 5-LOX
  • 5LPG
  • LOG5