ALDH1A2 gene

aldehyde dehydrogenase 1 family member A2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

From UniProt:

Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity).

Cytogenetic Location: 15q21.3, which is the long (q) arm of chromosome 15 at position 21.3

Molecular Location: base pairs 57,953,424 to 58,065,923 on chromosome 15 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 15q21.3, which is the long (q) arm of chromosome 15 at position 21.3
  • RALDH(II)
  • RALDH2
  • RALDH2-T