AKR1C2 gene
aldo-keto reductase family 1 member C2
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
From UniProt:
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
Related Information
Cytogenetic Location: 10p15.1, which is the short (p) arm of chromosome 10 at position 15.1
Molecular Location: base pairs 4,987,775 to 5,018,033 on chromosome 10 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- AKR1C-pseudo
- BABP
- DD
- DD-2
- DD/BABP
- DD2
- DDH2
- HAKRD
- HBAB
- MCDR2
- SRXY8
- TDD