AIMP2 gene

aminoacyl tRNA synthetase complex interacting multifunctional protein 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]

From UniProt:

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Cytogenetic Location: 7p22.1, which is the short (p) arm of chromosome 7 at position 22.1

Molecular Location: base pairs 6,009,251 to 6,023,834 on chromosome 7 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 7p22.1, which is the short (p) arm of chromosome 7 at position 22.1
  • HLD17
  • JTV-1
  • JTV1
  • P38