AGGF1 gene

angiogenic factor with G-patch and FHA domains 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]

From UniProt:

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.

From UniProt:

Klippel-Trenaunay syndrome (KTS): Congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. [MIM:149000]

Cytogenetic Location: 5q13.3, which is the long (q) arm of chromosome 5 at position 13.3

Molecular Location: base pairs 77,030,385 to 77,065,234 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q13.3, which is the long (q) arm of chromosome 5 at position 13.3
  • GPATC7
  • GPATCH7
  • HSU84971
  • HUS84971
  • VG5Q