ADNP gene

activity dependent neuroprotector homeobox

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

From UniProt:

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

From NCBI Gene:

  • Helsmoortel-van der aa syndrome

From UniProt:

Helsmoortel-van der Aa syndrome (HVDAS): A disorder characterized by intellectual disability, autism spectrum disorder, and dysmorphic facial features including prominent forehead, high hairline, downslanting palpebral fissures, notched eyelids, broad nasal bridge, thin upper lip, and smooth philtrum. [MIM:615873]

Cytogenetic Location: 20q13.13, which is the long (q) arm of chromosome 20 at position 13.13

Molecular Location: base pairs 50,888,918 to 50,934,984 on chromosome 20 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 20q13.13, which is the long (q) arm of chromosome 20 at position 13.13
  • ADNP1
  • HVDAS
  • MRD28