ADAMTS3 gene

ADAM metallopeptidase with thrombospondin type 1 motif 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]

From UniProt:

Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

From NCBI Gene:

  • HENNEKAM LYMPHANGIECTASIA-LYMPHEDEMA SYNDROME 3

Cytogenetic Location: 4q13.3, which is the long (q) arm of chromosome 4 at position 13.3

Molecular Location: base pairs 72,280,969 to 72,568,799 on chromosome 4 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 4q13.3, which is the long (q) arm of chromosome 4 at position 13.3
  • ADAMTS-4
  • HKLLS3